Molecular Cloning of the CA125 Ovarian Cancer Antigen
نویسندگان
چکیده
منابع مشابه
Deciphering the Molecular Nature of Ovarian Cancer Biomarker CA125
The ovarian cancer biomarker CA125 has been extensively investigated over the last 30 years. The knowledge about the exact molecular nature of this protein, however, remains fragmented. This review provides an overview of the structural research regarding CA125, and presents an orthogonal verification method to confirm the identity of this molecule. The need for independent identification of CA...
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A quarter of a century since its discovery, circulating CA125 antigen is recommended for clinical use in the USA for ovarian cancer screening of high-risk women with ovaries, despite its limited sensitivity and specificity. Recent findings suggest that CA125 might also serve as a predictive marker for pre-invasive ovarian carcinoma. Methods to quantify circulating CA125 evolved toward sensitive...
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Screening trials for the early detection of ovarian cancer in the general population and in patients at a high risk for this disease have so far failed to show a reduction of ovarian cancer-specific mortality. Current screening modalities include pelvic examinations, transvaginal ultrasounds, and cancer antigen 125 (CA125) serum marker levels, which are associated with a high false-positive rat...
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M onitoring ovarian cancer with regular blood tests for the CA125 biomarker is a firmly embedded practice in oncology, the theory being that rising CA125 levels may indicate a recurrence, which can be treated effectively upon early detection. But results from a new randomized, controlled trial presented at the annual meeting of the American Association of Clinical Oncology (ASCO) earlier this y...
متن کاملConstruction and expression of a single chain antibody mimicing human ovarian cancer antigen CA125.
One concept for immune therapy of cancer involves induction of antigen mimic antibodies to trigger the immune response against tumor cells. Anti-idiotypic antibodies directed against the antigen-binding site of antibodies specific for tumor antigen may functionally and even structurally mimic antigen and induce anti-anti-idiotypic immune response. Monoclonal antibody WJ02 is one of such anti-id...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m103554200